JAMA, the American Medical Association journal, published the Effectiveness of Fecal Microbiota Transplantation for Weight Loss in Patients With Obesity Undergoing Bariatric Surgery today (2022-12-16).
Research Animation: The kidney microbiota, as a potential target for treating obesity, has aroused people's interest. Stool microbiota transplantation (FMT) can effectively treat obesity in mouse models. The difference between the microbiota of the lean and fat people and the causal relationship between the microbiota and weight in animal models contributes to the FMT treatment of obesity and symptomatology. FMT has all improved slightly on insulin sensitivity, abdominal obesity and lipid elimination, but has so far less impact on body weight. Despite successful microbial implantation, the benefits achieved seem to be short-lived. Compared with the health control group, most severely obese patients have reduced bacterial diversity and microbial gene richness, but fat loss surgery can improve the microbial gene richness. We conducted this random clinical trial controlled by consolation to study the effects of FMT-rich tract microbiome on fattening surgery results.
Study: Participants must meet two criteria: (1) Body weight index (BMI) is greater than 40 or 35 (if the patient has a combination of obesity-related disorder, e.g. 2 (2) There is no pregnancy, type 1 diabetes, severe kidney dysfunction, esophageal reflux, and chronic or recurrent bacterial infections that require antibacterial drugs. As a result, a total of 41 people met these two conditions, 29 of whom were women, and the average age of the whole was 49 years old. These 41 people were randomly assigned to treatment groups (21 people) or condolence groups (20 people). However, due to various factors, only 19 people from the treatment group and 15 people from the consolation group completed the experiment.
Research Methods: Obese patients received FMT 6 months before the expected obesity surgery (using gastric lens to implant the twelve-fingered kidney samples). The patients in the treatment group were implanted with lean squid samples, while those in the comfort group were implanted with their own squid samples. During the 4-week period before the surgery, all patients took extremely low-temperature diets.
Two 40-year-olds provide samples of slim dysfunction (treated stool). They are all healthy foodies (eating rich vegetables), and their BMIs are less than 20 and less than 25 respectively.
Results: Six months after implantation of the kidney bacteria sample (approximately obesity surgery), the average weight reduction for those in the treatment group was 4.8%, while for those in the comfort group was 4.6%. At 18 months of implantation of the kidney bacteria sample (12 months after obesity surgery), the average weight reduction for those in the treatment group was 25.3%, while for those in the comfort group was 25.2%.
Conclusion: The implantation of slim tract bacteria samples did not affect the reduction of pre- or post-operative weight. (Note: The weight loss at 6 months is due to the extremely low-heat diet, while the weight loss at 18 months is due to surgery)
Original text: Can the leukorrhea make fat people thin?