You can first know: (1) Mice suffering from Alzheimer's disease are more severe under sufficient vitamin D nutrition conditions, but this can only be explained as "eating more vitamin D is harmful if you are sick", not "eating more vitamin D will get sick if you are sick."
(2) The study was mouse experiments, and animal experiments did not mean that humans had the same effect.
(3) The health care database studies the use of "active vitamin D" groups belonging to "pharmaceuticals", which are not "inactive vitamin D" that ordinary people buy and eat, which belongs to "nutritional supplements".
(4) Ethnic groups that use active vitamin D are mostly kidney patients. kidney patients are originally high-risk ethnic groups. This data analysis should be "related" rather than "causal relationship".
The post "The more vitamin D eats, the more brain cells may die?!" The post mentioned the animal experiment with Alzheimer's disease. It was observed that supplementing vitamin D can aggravate the condition, and the analysis of Taiwan's health care data library also showed the same results. But experts say that animal experiments do not represent humans, and the health care database analyzes the "active vitamin D" used for medicines, and is not the "inactive vitamin D" nutrient that ordinary people eat.
Eating vitamin D Is dementia caused by dementia? Original epistem version:Research by the National Institute of Health: Long-term, high-dose supplementation of vitamin D for the elderly, the risk of dementia will not decrease but increase
and spread related content on social platforms and news:
The rumor mentioned that "in an animal experiment with Alzheimer's disease, vitamin D was clearly observed, "accelerating" brain neuronal cell death and aggravating cognitive degeneration." The research quoted was "Viostasis of Vitamin D aggravating the progress of Alzheimer's disease: Animal Models and Human Cybersearch Research" published by the Taiwan Institute of Aging Cell in August 2022.
The Ministry of Welfare also held a reporter meeting at that time. The news manuscript stated that the study was divided into two parts. The first part was the study team's experiment using mouse animals. It found that under the conditions of adequate vitamin D, Alzheimer's disease mice had low blood vitamin D, but the amount of vitamin D receptor protein in the brain increased instead of reducing, and it was in conjunction with the age spots of the senile powder that caused neuropathy in the brain.
The second part is that after obtaining the above-mentioned test results, the research team used the Taiwan Health Care Database for analysis and found that if an elderly person who does not suffer from dementia takes "active vitamin D3" (calcitriol) every year, the risk of dementia is 1.8 times that of unused patients; if a patient with dementia is 2.17 times that of unused patients, these numbers are the main content of the rumor.
(1) Animal experiments are not equivalent to humansMyGoPen consulted Fu Zhongling, deputy director of the Taipei Rongsheng Neurological Medicine Center and permanent director of the Taiwan Clinical Dementia Association. She said that the first part of the study was to use Alzheimer's disease mice, so it should be explained that eating more vitamin D for Alzheimer's disease is harmful, rather than eating vitamin D without illness. You will get sick, but Alzheimer has been stuck in his brain for twenty years before he became ill. If there is no examination of the elixir, the public will not know if they have pathological changes. The clinical suggestion is that if there is no memory problem at present, it is not recommended to do the examination and do it if there is any symptoms. Fu Zhongling pointed out that it is not certain whether the results of general animal experiments can be applied to people, but in fact, it is not certain in science. Therefore, good research will combine animal experiments and human clinical reports to gain trust from people.
(2) Experimental medicines are not commercially available vitamin DFu Zhongling emphasized that the data used in the research institute is to establish "active vitamin D3" in health care data. Different from the "inactive vitamin D3" bought and taken by ordinary people, it must meet the active vitamin D3 of health care. The conditions include: vitamin D rispermia, hypophosphorus rispermia; hypothyroidism in parathyroidism; hypothermia caused by chronic insufficiency; patients with spinal urgency fractures or fractures after cessation.
(3) The drug group used in the health care database is itself a high risk of dementia.Fu Zhongling pointed out that because other bone relieving drugs cannot be used, because other bone relieving drugs are not effective than the effect of active vitamin D3, less active vitamin D3 is selected as the main treatment drug. Therefore, the active vitamin D3 population of health insurance not only has some disease conditions, but many are even used because of poor kidney function. However, patients with poor kidney function are known to have a higher incidence of dementia. The rate of chronic kidney disease and dementia is as high as more than 30%. It can be said that the worse the kidney function, the higher the proportion of dementia. Fu Zhongling said that when the National Institute of Health first published this study, it had sparked a dispute. Many experts believed that the National Institute of Health's research showed "relevance" rather than an inevitable "causal relationship". Fu Zhongling emphasized, "I also agree with the above views."
Fu Zhongling called out that causal research is very difficult. Most of the research is related research, so the conclusion usually requires a more conservative writing. However, some studies are abolished and easy to cause misleading during the public dissemination process. When the public receives relevant rumor messages, they should be able to see the content carefully or search for public and credible data to compare and compare..
The research mentioned in the speech is divided into two parts: mouse animal experiment and health care database analysis. Among them, mouse experiment is the result of the diseased mice giving vitamin D, so the conclusion should be explained that eating vitamin D is already sick. Harmful, not healthy people will get sick by eating vitamins, but the actual situation is that ordinary people don’t know that they already have Alzheimer’s disease before they develop symptoms. The value of this study should help more and more important breakthroughs in the future, but there is a gap with the value of the public, so the public does not need to misunderstand or be overly surprised. The second part of the study was to analyze health care data banks, but the data obtained was to use "active vitamin D3", but ordinary people eat "inactive vitamin D3" (cholecalciferol). Active vitamin D3 is a medicine, and inactive vitamin D3 is a nutritional supplement. What people receive from diet, health food or daily necessities are "inactive vitamin D3". Experts also said that the active vitamin D3 groups using health insurance are mostly kidney patients, and kidney patients themselves are high-risk groups of dementia. This study is a conclusion of "related" research, not "causal relationship".
(This article is reproduced from "MyGoPen" verification reference: https://www.mygopen.com/2023/12/vitamin-d.html)
(Editor in charge: Ye Zicen)